Fri Dec 26 2025

81 articles - From Friday Dec 19 2025 to Friday Dec 26 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Clin Gastroenterol Hepatol
International Expert Delphi Consensus on EUS Guided Portosystemic Pressure Gradient: Best Practices and Future Directions.

The results of this modified Delphi process established expert agreement on multiple important issues and provided practical guidance on key aspects of EUS-PPG. This document could provide a roadmap for future research studies.

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Gastrointest Endosc
Quality indicators for endoscopic retrograde cholangiopancreatography.

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Gut
Revised version global guidelines on diverticular disease of the colon: the Fiesole Consensus report.

These Consensus statements aim to standardise and optimise the diagnosis, management and prevention of diverticular disease across diverse healthcare systems, while highlighting research priorities such as microbiome characterisation, genetic risk profiling and long-term outcomes of selective antimicrobial and surgical strategies.

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Meta-analysis

meta-analyses and systematic reviews

Gastroenterology
The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis.

Core microbial perturbations at onset of CD and UC are depletion of anaerobes and enrichment of oxygen-tolerant, orally associated bacteria. As we place greater emphasis on early diagnosis and prediction of IBD risk, this finding may support innovative diagnostic approaches. Microbiome-targeted intervention and alteration of luminal oxygen availability may offer novel therapeutic avenues for new-onset patients and identified high-risk groups.

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Gastrointest Endosc
Accuracy of Virtual Scale Endoscopy in Colorectal Polyp Size Measurement: A GRADE-Assessed Pairwise and Network Meta-Analysis.

VSE significantly improves polyp sizing accuracy compared to VA, snare, and forceps across both clinical and pre-clinical settings. NMA supports VSE as the top-ranking modality, suggesting its potential to enhance decision-making in polypectomy and surveillance. Larger multi-center trials are needed for validation.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther
Comprehensive Risk Profile of Gastrointestinal and Extra Articular Comorbidities in Ehlers-Danlos Syndrome: A Propensity-Matched Analysis of 118,256 Individuals.

EDS patients exhibit heightened risk for GI, systemic and psychological comorbidities, highlighting the importance of multidisciplinary approaches for effective management.

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Research Communication: Sexual Dysfunction is a Common Early Challenge in Newly Diagnosed Inflammatory Bowel Disease.

Sexual dysfunction was independently associated with disability and bowel urgency in UC, and with hospitalisation, impaired quality of life, and fatigue in CD, but not IBD activity or treatment. These findings support early recognition of sexual dysfunction as part of patient-centred IBD care.

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Spontaneous Bacterial Peritonitis Is Associated With High Mortality, Which Interacts With Antibiotic Prophylaxis in a National Cirrhosis Cohort.

In a national cohort of newly decompensated cirrhosis Veterans, SBP increased mortality, which worsened with recurrence. SBP prophylaxis (primary or secondary) showed an interaction with higher mortality but not LT. Antibiotic resistance increased with SBPPr, but culture results were not followed while resuming/initiating SBPPr. Novel strategies to prevent SBP recurrence and mortality are needed.

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Stability of Classification Systems for Irritable Bowel Syndrome.

Different IBS classifications showed only moderate stability over 12 months, highlighting the fluctuating nature of the disorder. Stool form and psychological burden-based systems were most stable, but no method fully captured IBS variability. Future work could develop dynamic models integrating gastrointestinal and psychological factors to better guide management.

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Am J Gastroenterol
Association Between CT-Based AI-Derived Body Composition and Survival in Patients With Pancreatic Ductal Adenocarcinoma.

Body composition parameters, derived from CT scans at the time of PDAC diagnosis, particularly low skeletal muscle density, sarcopenic obesity, and low adipose tissue, are independently associated with OS in patients with PDAC. Evaluating body composition at diagnosis could enhance clinical decision-making and enable more personalized treatment strategies.

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Ethical and Legal Considerations for Responsible Use of AI in Clinical Gastroenterology.

Here, we present an overview of the core principles of responsible use of healthcare AI, including equity and fairness, patient autonomy, data privacy and security, accountability for AI-related patient harm, human agency, and regulation, using GI-relevant examples to highlight the benefits and risks of this powerful technology. We conclude with our predictions regarding the future legal and ethical impact of AI in our field.

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Sevoflurane Dose and Timing Affects Esophageal Contractility During Functional Lumen Imaging Probe.

The timing and dose of sevoflurane is strongly associated with esophageal CR impairment during FLIP.

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Clin Gastroenterol Hepatol
Clinical Characteristics and Treatment Outcomes in Patients with Incomplete Microscopic Colitis: Consideration for Expanding the Definition of Microscopic Colitis.

In one of the largest cohorts of MCi, the majority were on drugs implicated in MC and almost three-fourths had a complete response to therapy including budesonide. Given the commonalities with MC, the histologic definition should potentially be expanded to include these patients.

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Randomized Controlled Trial of Upper Esophageal Sphincter Assist Device in Laryngopharyngeal Reflux Disease.

In this randomized double-blinded controlled trial of patients with LPRD, significant differences in laryngopharyngeal symptoms were not seen between application of the UESAD at therapeutic versus lower pressures. Laryngopharyngeal symptoms as well as pepsin concentrations significantly improved among both groups suggesting that application of external cricoid pressure, even at lower levels, is a safe, non-invasive, well-tolerated and effective therapy for LPRD. (ClinicalTrials.Gov NCT04827355).

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Endoscopy
Opportunities to reduce the environmental impact of endoscopy: a detailed material flow analysis of diagnostic colonoscopy.

Plastic-based materials formed the largest contributor to the total used product weight. These findings inform decision-makers in designing targeted interventions to reduce the environmental impact of diagnostic colonoscopy, for example by considering more sustainable materials such as fiber-based materials. The prepared visual map makes waste generation discussable among healthcare professionals, thereby supporting a collaborative approach to identify sustainable opportunities.

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The value of routine endoscopic ultrasound in patients with esophageal cancer after neoadjuvant chemoradiotherapy undergoing active surveillance.

EUS with FNA adds most value at 3 months post-nCRT, when the likelihood of detecting recurrence is highest. Beyond 3 months, its added value is limited (0.1% with negative PET-CT). Restricting the use of EUS to PET-suspicious nodes could omit 97.8% of EUS procedures.

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Gastroenterology
Depletion of Fibrinogen Suppresses Growth of Primary Tumors and Metastasis of Pancreatic Ductal Adenocarcinoma.

These data suggest that fibrin(ogen) reprograms the primary tumor microenvironment to support growth and promote early, but not late, metastatic steps. Our findings support prospective evaluation of a novel clinical approach involving the integration of fibrin(ogen)-targeting or depleting agents into chemotherapy regimens to control the spread of pancreatic cancer.

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Prognostic Performance of Phosphatidylethanol With Noninvasive Liver Fibrosis Tests in Alcohol-Related Liver Disease.

PEth predicts hepatic decompensation independently of fibrosis-based NITs in individuals at risk of ALD. Although its prognostic performance declines rapidly, repeated PEth measurements maintain prognostic discrimination.

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Gastrointest Endosc
Diagnostic yield of EUS-guided fine-needle biopsy of solid pancreatic lesions with tissue sent directly in formalin for histopathological evaluation compared to cytology: a multi-center prospective pilot study.

Histopathologic analysis of EUS-FNB samples provides diagnostic accuracy comparable to cytology and supports broader adoption in settings without cytopathologists.

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Gut
Circulating HBV RNA and HBsAg seroconversion in patients with chronic HBV infection: a long-term follow-up study starting from childhood in Taiwan.

In this long-term chronic HBV cohort, we elucidated both the natural course and antiviral-related HBsAg seroconversion. Undetectable circulating HBV RNA and percentage of A2131C mutants <10% after HBeAg seroconversion are novel and independent predictors of HBsAg seroconversion.

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Comparison between germline and somatic loss-of-function <i>RNF43</i> mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis.

Background Germline variants confer higher risk, although weak effects of C-terminal variants cannot be excluded. Genetic testing and patient management should incorporate these factors.

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Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women.

This study provides preliminary evidence that a probiotic fermented dairy product can modulate hippocampal-related outcomes.

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Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis.

The underlying mechanisms driving malignant transformation by CP remain poorly understood. Objective Combining a recently developed mouse model of CP carrying the human carboxypeptidase A1 ( in early pancreatic carcinogenesis.

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Metabolomic pattern of ultraprocessed food intake and its association with colorectal cancer risk.

We developed a UPF metabolomic pattern. The pattern and several metabolites were associated with CRC risk, providing biological insights into potential pathways underlying the UPF-CRC relationship.

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Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer.

This work provides functional evidence for the causal role of secondary BAs produced by gut bacteria through 7αDH in CRC under adverse dietary conditions, opening avenues for future preventive strategies.

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Tracking B cell immunity during perturbation of hepatitis B infection induced by treatment withdrawal.

Differences in global and HBs-specific B cell immunity associate with HBsAg loss, whereas HBc-MBC temporally associates with flares, following withdrawal of prolonged NA treatment. Our results underscore the need to further explore the potential of B cell targets for monitoring and enhancing HBV functional cure in larger cohorts.

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Twenty-four-week anti-PD-1 antibody regimen promoted HBsAg reduction and concurrently enhanced HBV-specific T cell responses in patients with chronic hepatitis B.

In virally suppressed CHB patients on NA therapy, 24-week half-dose sintilimab treatment demonstrated a favourable safety profile. This regimen can facilitate HBsAg reduction and even HBsAg loss, while concurrently enhancing HBV-specific T-cell responses. These findings support αPD-1 as a potential therapeutic alternative for CHB.

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Hepatology
Biology-driven stratification of advanced biliary tract cancer treated with nab-paclitaxel plus gemcitabine-cisplatin: A prospective observational cohort study.

This study demonstrated the clinical activity of Gem/Cis/nab-P in advanced BTC and highlighted that biology-driven patient stratification based on genomic and transcriptomic features may provide important prognostic information.

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J Hepatol
Modeling Immune Lineage Co-Development in Human Pluripotent Stem Cell-derived Liver Organoids.

FLOs establish a physiologically relevant model for multi-lineage hemato-hepatogenesis and innate immunity in the liver. By recapitulating critical fetal liver tissue functions, FLOs provide a translational platform for studying human fetal liver development, immune-mediated hepatic injury, and regenerative therapies in humans. Impact and implications This study establishes a human pluripotent stem cell-derived Fetal Liver-like Organoid (FLO) system that reconstitutes hepato-hematopoietic co-development and innate immune function. FLOs offer a human platform to dissect cross-lineage signaling during liver development and immune-mediated injury. Clinically and translationally, FLOs enable mechanistic modeling of pediatric liver diseases and regenerative interventions, offering a tractable in vitro system for preclinical screening and precision-medicine approaches.

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Use of intracranial pressure monitoring and risk factors for the development of intracranial hypertension in acute liver failure.

In three high-volume liver transplant units, the use of invasive ICP monitoring fell significantly over a ten-year period and was not associated with worsening outcomes. Based on the data presented it can be suggested that a focus on early preventative measures without invasive ICP monitoring is a rational approach and does not lead to adverse outcomes, including ICH, CD or increased mortality. Impact and implications With advances in ICU supportive care, the incidence of intracranial hypertension as a complication of ALF, has fallen. Serum ammonia levels are central to the pathogenesis and risk stratification. Invasive ICP monitoring remains the gold standard for detection, but availability, concerns about utility and complications have limited its application. Our study shows that a reduction in use was not associated with a change in patient-centred outcomes.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther
Editorial: Extracellular Matrix Biomarkers Illuminate the Architecture of Portal Hypertension in End-Stage Liver Disease.

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Editorial: The Hidden Burden-Stigmatisation in Inflammatory Bowel Disease.

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Clin Gastroenterol Hepatol
Blue Notes.

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Gastrointest Endosc
A note from the Editor-in-Chief.

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Advancing stricture prevention after circumferential esophageal endoscopic submucosal dissection.

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Closing the loop: electronic adverse events monitoring.

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Depth and dilemma: endoscopic submucosal dissection's efficacy in deep versus superficial colorectal cancer.

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Emergent peroral endoscopic myotomy for esophageal motility disorders: defining its evolving clinical role.

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Endoscopic biliary drainage in surgically altered anatomy: endoscopic ultrasound to the forefront.

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Endoscopic ultrasound--guided gallbladder drainage to 1 year and beyond.

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Endoscopic ultrasound-guided phosphorus-32 therapy in pancreatic cancer: a signal worth pursuing.

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Indefinite for dysplasia in Barrett's esophagus: definitely worth your attention.

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Riding the therapeutic wave in the second duodenum: underwater papillectomy as a new frontier in ampullary neoplasms.

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Submucosal steroid preinjection strategy versus combined steroid therapy to prevent postcircumferential endoscopic submucosal dissection esophageal stricture.

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The debate continues: What is the best needle and technique for Endoscopic ultrasound-guided liver biopsy?

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J Hepatol
What's next after the 2025 BCLC update?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol
Letter to the Editor.

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Letter to the Editor.

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Pelviperineal Malakoplakia.

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Primary Esophageal Yolk Sac Tumor: A Rare Cause of Dysphagia.

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Clin Gastroenterol Hepatol
Rising intrahepatic cholangiocarcinoma rates in the United States are driving liver cancer rates in females [Characters: 108/120].

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Endoscopy
A case of cirrhosis with gastric varices and hypersplenism treated by endoscopic ultrasound-guided devascularization and partial splenic embolization (with video).

Pubmed   Journal   ReadQx   PMC

Endoscopic filling with polyglycolic acid sheets and fibrin glue for esophagomediastinal fistula after per-oral endoscopic myotomy.

Pubmed   Journal   ReadQx   PMC

Endoscopic recanalization of a complete choledochojejunal anastomotic stricture using the "piercing technique" via an endoscopic ultrasound-guided hepaticogastrostomy approach.

Pubmed   Journal   ReadQx   PMC

Same-session aspiration of unexpected ascites and endoscopic ultrasound-guided gastroenterostomy in gastrojejunal anastomotic stenosis.

Pubmed   Journal   ReadQx   PMC

Single-use gastroscopes: evolution postponed.

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Successful endoscopic biliary intervention using a rotatable sphincterotome and a multi-ring traction device.

Pubmed   Journal   ReadQx   PMC

Gastroenterology
History of sexual violence: a gastroenterologist's concern?

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THE SENENDO VOLUNTEER MISSION - A TRAINING AND CARE DELIVERY MODEL THAT ADDRESSES LACKING DIGESTIVE ENDOSCOPY RESOURCES IN SUB-SAHARAN AFRICA.

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Gut
CD177+ neutrophils: new drivers of liver regeneration.

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Hepatocyte guardian: A20 restrains ferroptosis in autoimmune hepatitis.

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Just right: neutrophils exemplify the Goldilocks principle in liver regeneration.

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Hepatology
Discontinuing Letters to the Editor: Loss of utility and pertinence.

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Letter to the Editor: The suggestion for additional clinical scores in decoding tumor heterogeneity in HCC.

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Letter to the Editor: When locoregional therapy fails, how soon should we pivot?

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Reply: The suggestion for additional clinical scores in decoding tumor heterogeneity in HCC.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther
Editorial: Extracellular Matrix Biomarkers Illuminate the Architecture of Portal Hypertension in End-Stage Liver Disease-Authors' Reply.

Pubmed   Journal   ReadQx 

Editorial: The Hidden Burden-Stigmatisation in Inflammatory Bowel Disease: Authors' Reply.

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Letter: Intestinal Ultrasound: The Evidence Is Catching Up With the Technology.

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Gastroenterology
Comments on Hepatic Stellate Cell Regulation in Metabolic Dysfunction-Associated Steatohepatitis.

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Refining Meta-Analyses of GLP-1RA Safety: Sparse Event Data, Confounding, and Sex Differences.

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Gastrointest Endosc
A case series is not enough to properly study potential adverse events of the endoscopic over-the-scope clips and cutters.

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Advancing walled-off necrosis management: multidimensional applications of validated quadrant, necrosis, and infection risk stratification.

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On subgroup analysis, behavioral confounding, and procedural generalizability in endoscopic sleeve gastroplasty research.

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Refining the interpretation of recurrence risk in T1 rectal cancer: insights from a clinical standpoint.

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Reflections on obesity-related adverse events after endoscopic sleeve gastroplasty.

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Reproducibility, anatomical considerations, and postablation healing in hybrid argon plasma coagulation after endoscopic mucosal resection of large colorectal polyps.

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Toward a holistic evaluation of endoscopic sleeve gastroplasty outcomes.

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Gut
Endoscopic gastroenterostomy for malignant gastric outlet obstruction: the need for reintervention is variable.

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J Hepatol
Emergency granulopoiesis-linked module activation in PBMC transcriptomes associates with adverse outcomes in HBV-related cirrhosis with acute decompensation.

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Integration of Particle Therapy into the Updated BCLC Strategy for Hepatocellular Carcinoma.

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